Author/Authors :
Öztemür, Zekeriya Cumhuriyet Üniversitesi - Tıp Fakültesi - Ortopedi ve Travmatoloji Anabilim Dalı, Turkey , Tezeren, Gündüz Cumhuriyet Üniversitesi - Tıp Fakültesi - Ortopedi ve Travmatoloji Anabilim Dalı, Turkey , Durmuş, Nedim Sağlık Bakanlığı İlaç ve Tıbbi Cihaz Kurumu - Farmakovijilans Risk Yönetimi Birimi, Turkey , Bağcıvan, İhsan Cumhuriyet Üniversitesi - Tıp Fakültesi - Farmakloji Anabilim Dalı, Turkey , Saraç, Bülent Cumhuriyet Üniversitesi - Tıp Fakültesi - Farmakloji Anabilim Dalı, Turkey , Öztürk, Hayati Cumhuriyet Üniversitesi - Tıp Fakültesi - Ortopedi ve Travmatoloji Anabilim Dalı, Turkey , Bulut, Okay Cumhuriyet Üniversitesi - Tıp Fakültesi - Ortopedi ve Travmatoloji Anabilim Dalı, Turkey
Abstract :
Aim. Evaluation of corpus cavernosum and motor function after early surgical decompressssion on acute spinal cord injury. Method. We initiated the study with 21 New Zealand male rabbit. The animals were assigned to four groups which were sham group (n=6), laminectomy group (n=5), 15 seconds compression group (n=5) and 60 seconds compression group (n=5). Fifteen seconds or 60 seconds compression applied to compression group in 60 gram compression force with aneurysm clips. We evaluated motor system with modified Tarlov score at 1st, 3rd, 5th and 7th days of cord injury. All rabbits are sacrificed after 7 day postoperatively. Histopathological evaluations are made on spinal cord and in vitro relaxation and contraction tests were performed on urinary bladder and corpus cavernosum tissues in tissue baths. Results. There was significant difference between all groups according modified Tarlov score (p 0.05). Maximum relaxation response of the corpus cavernosum with carbachol was similar between 15 seconds compression group and 60 seconds compression group and maximum relaxation response of the corpus cavernosum with carbachol decreased in compression group compared with laminectomy and sham groups (p 0.05). pD2 values were similar in four groups (p 0.05). Conclusion. The model used in this study showing the efficacy of early surgical decompression in acute spinal cord injury may be useful to investigate the effects of agents for sexual dysfunction in vitro. Early surgical decompression may develop the motor and corpus cavernosum functions after acute spinal cord injury. In addition, phosphodiesterases type V inhibitors may be useful for treating erectile dysfunction in spinal cord injured patients.
