مرکز منطقه ای اطلاع رساني علوم و فناوري - Lornoxicam - a newer oxicam for postoperative pain relief in patients undergoing abdominal hysterectomy

Abstract :

Aim. The present study evaluated the analgesic effect of lornoxicam- a new thienothiazine derivative of the oxicam class of non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative pain relief in patients undergoing abdominal hysterectomy. Method. The study included 50 adult female patients having physical status ASA grade I II undergoing abdominal hysterectomy under general anaesthesia. Patients were administered lornoxicam 8 mg intramuscular at closure of the wound and were repeated 12 hourly for the next 48 hours. Intravenous morphine was used as rescue analgesia with patient controlled analgesia pump. Result. The total mean requirement of morphine was 50.0±4.74 mg during the study period. Mean requirement of morphine in first 24 hours and between 24-48 hours was 37.80±3.81 mg and 12.20±4.99 mg respectively. The mean requirement of morphine at different time intervals during the study i.e. from 0-6 hours was 14.7±2.13 mg, from 6-12 hours was 11.80±3.69 mg and from 12-24 hours, it was 11.30±3.05 mg. The requirement of morphine from 24-36 and 36-48 hours was 6.20±3.40 and 6.0±3.24 mg respectively. Conclusion. The requirement of morphine decreased significantly in the second half of the study. The requirement of morphine continued to decrease with each passing hour in the present study. Further, larger trials are needed to establish its efficacy as an analgesic for postoperative pain relief in different surgeries.