Şahan, Abdülkadir Geylani Gaziosmanpasa University - School of Medicine - Department of Internal Medicine, Turkey , Yılmaz, Abdülkerim Gaziosmanpasa University - School of Medicine - Department of Internal Medicine, Turkey , Taşlıyurt, Türker Gaziosmanpasa University - School of Medicine - Department of Internal Medicine, Turkey , Doruk, Sibel Gaziosmanpasa University - School of Medicine - Department of Pulmonary Diseases, Turkey , Köseoğlu, Handan İnönü Gaziosmanpasa University - School of Medicine - Department of Pulmonary Diseases, Turkey , Şıvgın, Hakan Gaziosmanpasa University - School of Medicine - Department of Internal Medicine, Turkey , Sağcan, Mustafa Gaziosmanpasa University - School of Medicine - Department of Internal Medicine, Turkey

Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

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Aim. Chronic obstructive pulmonary disease (COPD) is a chronic, progressive, inflammatory disease. Oxidative stress and airway inflammation are its main pathophysiologic components. In this study, our aim was to investigate the effect of an angiotensin receptor blocker (ARB) telmisartan which also exerts antiinflammatory effects on inflammation and oxidative stress in COPD. Method. The study group consisted of 50 stable COPD patients including 25 telmisartan users. Exhaled breath condensate (EBC) samples of the cases were collected using an EBC collecting device (Ecoscreen, Jaeger, Germany). EBC samples were analyzed and 8-isoprostane levels were measured using an enzyme immunoassay method (Cayman Chemical Co. Michigan, USA). Results. Any intergroup difference as for mean age, distribution of gender and smoking were not found. In telmisartan users, and nonusers mean 8-isoprostane levels were 33.98 and 35.91 pg/mL, respectively with a statistically significant intergroup difference (p 0.001) Conclusion. We think that ARBs decrease oxidative stress and inflammation, and thus exert favourable effects on the pathophysiology and progression of COPD.

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Chronic obstructive pulmonary disease , oxidative stress , 8 , isoprostane , angiotensin receptor blocker , telmisartan

Cumhuriyet Medical Journal

183