Ersöz, Cevriye Cansız Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Kankaya, Duygu Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Kiremitçi, Saba Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Kaygusuz, Gülşah Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey

DOG1 expression profile of benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas

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Aim. DOG1 is a calcium-dependent chlorid channel, that shows specific expression in Gastrointestinal stromal tumors (GIST) can be used in differential diagnosis of these tumors with other soft tissue sarcomas. In several studies, DOG1 expression has been reported in varying proportions in Non-GIST mesenchymal tumors. In this study, we aimed to find the DOG1 expression profile in Nodular fasciit, Neurofibroma, Desmoid tumors and Dermatofibrosarcoma protuberans. Method. Nodular fasciit (n=8), Neurofibroma (n=8), Desmoid tumors (n=8) and Dermatofibrosarcoma protuberans (n=8) cases, diagnosed in Ankara University, Faculty of Medicine, Department of Pathology between 2005-2012, were included in this study. Results. Focal and pale DOG1 reactivity was seen only in one case of Nodular fasciit (1/8) whereas the remainig cases were negative with DOG1. Conclusion. DOG1 has no diagnostic value in benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas.

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DOG1 , neurofibroma , nodular fasciitis , desmoid tumor , dermatofibrosarcoma protuberans

Cumhuriyet Medical Journal

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