Author/Authors :
Doğan, Abdullah Sezai Manavgat Aile Sağlığı Merkezi - Aile Hekimliği, Turkey , Yenicesu, Cem Cumhuriyet Üniversitesi - Tıp Fakültesi - Aile Hekimliği Anabilim Dalı, Turkey , Sucaklı, Mustafa Haki Sütçü İmam Üniversitesi - Tıp Fakültesi - Aile Hekimliği Anabilim Dalı, Turkey , Özdemir, Öztürk Onsekiz Mart Üniversitesi - Tıp Fakültesi - Tıbbi Genetik Anabilim Dalı, Turkey , Demirel, Yeltekin Cumhuriyet Üniversitesi - Tıp Fakültesi - Aile Hekimliği Anabilim Dalı, Turkey
Abstract :
Aim. It is observed in studies that hypertension is a feature of familial and a variety of gene polymorphism is associated with hypertension. Method. This study was planned in two stages.At the first stage; to evaluate gene mutation, in population under the age of 45 CVD (Cardiovascular Disease) case group of 50 persons with essential hypertension and at the same age group and sex, within normal blood pressure limits in a control group of 50 people was selected.In the second stage, cases of first-degree relatives of patients with homozygous polimorfizm DD ACE gene group (parents and siblings) family group of 50 people, were evaluated for genetic polymorphism. Results. Those with cases of allele ApoE3/E4 group, 88.9% had a family history of hypertension. In the same way, in all of those with the E3/E2 genotype, family history was positive. In the case group, 5 people (10%) E3/E2 ApoE gene polymorphism, 9 patients (18%) had APOE E3/E4 gene polymorphism. In the control group, these numbers was about respectively, 7, and 3 (14% and 6%).In the control group, ApoE3/E2 gene polymorphism, higher than control group (p 0.05). Case group E3/E4 genotype, higher than the control group; but this difference was not statistically significant. Total cholesterol 200 mg/dL and above those 62.5% of people were in the case group and this ratio compared to control group (37.5%) were significantly higher (p 0.05). In the family group, this rate was 66%. The mean values of HDL was lower in the 3 groups (case group, 41.9 ± 11.2, family group, 40.4 ± 13.4 and control group 44.9 ± 15.24 mg/dL).Mean LDL values were determined as 133.6 ± 32.2 mg /dL in case group, 137.8 ± 30.8 mg/dL in family group, and 123.4 ± 32.9 mg /dL in control group. Total cholesterol/HDL cholesterol ratios were 4978 ± 1.41 in case group, 5.7 ± 2.3 in family group and 4670 ± 1.83 in control group. The prevalence of hypertension was 56% in family group, (37% in individuals 45 years and under). 42.9% of those diagnosed before the age of 40 had hypertension. Conclusion. Both the case and the family group, cholesterol, LDL levels and total cholesterol/HDL ratio is high, low HDL levels, lipid values should be within normal limits suggests that lifestyle changes are necessary to bring. As a result, while the etiology of hypertension is querying, also genetic factors should be considered in, and studies on genes and hypertension should be held responsible.In addition, hypertensive patients should be monitorized for hypertension and other cardiovascular diseases by screening of all family members while they are being evaluated. Especially patients with hypertension was diagnosed before the age of 40 and their families should be monitored for both genetic and other risk factors (BMI, lipid profile, smoking, alcohol). Lifestyle changes which are important for hypertension prevention and control of hypertension should be employed.
