Author/Authors :
Cihan, Şener Okmeydanı Eğitim ve Araştırma Hastanesi - Tıbbi Onkoloji Kliniği, Turkey , Babacan, Nalan Akgül Marmara Üniversitesi - Pendik Eğitim ve Araştırma Hastanesi, Tıbbi Onkoloji Kliniği, Turkey , Odabaş, Hatice Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi - Tıbbi Onkoloji Kliniği, Turkey , Demirci, Nebi Serkan Ankara Numune Eğitim ve Araştırma Hastanesi - Tıbbi Onkoloji Kliniği, Turkey , Özdemir, Nuriye Yıldırım Ankara Numune Eğitim ve Araştırma Hastanesi - Tıbbi Onkoloji Kliniği, Turkey , Yazılıtaş, Doğan Ankara Numune Eğitim ve Araştırma Hastanesi - Tıbbi Onkoloji Kliniği, Turkey
Abstract :
Aim. Gallbladder cancer (GBC) is often diagnosed at advanced stage and prognosis is very poor. Information about the treatment of gallbladder cancer in the literature is limited. Most of the information were obtained from studies which involving liver, pancreas and other bile duct cancer. There is no standard therapy for metastatic disease. Various chemotherapeutic agents are used in the metastatic disease. In our study, effect of chemotherapy on survival in metastatic gallbladder cancer were investigated. Methods. Medical records of 32 patients with metastatic gallbladder cancer were evaluated retrospectively. Result. Both overall survival and progression free survival was longer in 14 (43.8%) patients receiving chemotherapy. This diversity was statistically significant (p 0.001). Progression-free survival was 20 ± 2.9 (14.3-25.7% CI) weeks and overall survival was 36 ± 11.2 (14-58% Cl) weeks in the patients receiving chemotherapy. On the other hand progression-free survival was 4 ± 0.4 (3.2-4.8% CI) weeks and overall survival was 12 ± 2.8 (6.5 x 17.5% CI) weeks in patients that didn’t receive chemotherapy. Gemcitabine/cisplatin and cisplatin/5-fluorouracil combinations were the most commonly used regimens. Conclusion. This study suggests that the positive effect of chemotherapy on survival in metastatic gallbladder cancer.
NaturalLanguageKeyword :
Gallbladder cancer , advanced stage , chemotherapy , survival
