inan, zeynep deniz şahin cumhuriyet university - faculty of medicine - department of histology and embryology, Turkey , saraydın, serpil ünver cumhuriyet university - faculty of medicine - department of histology and embryology, Turkey

Histological approaches to determination of stem cells in neural tube defects which are created experimentally

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Stem cells are cells that are started to be seen in the early stages of development and they have important roles in development of both neural system and other systems. Anomalies that occur with the neural tubes inability to close are known as neural tube defects. Neural tube defects can be due to malfunction of gene area and many mechanisms since the moment neural tube starts to develop. The incidence of neural tube defect is very high in our country and in the world. Therefore, to understand the neural tube defects in the people, necessary data is usually collected by giving teratogen agent to subject animals. With this compilation, experimental neural tube defects have been formed and immunohistochemistry and immunofluorescent studies of some stem cells that are thought to have role in the formation of defect are compiled. From this point of view, it is aimed to determine the distributions of neural tube in rhe processes of normal development and defect formation, to understand the reproduction and alteration mechanisms of stem cells, and concomitantly to reveal the defect pathogenesis.

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neural tube defects , stem cells , immunohistochemistry , immunofluorescent

Cumhuriyet Medical Journal

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