Author/Authors
ÖZTETİK, Elif Anadolu University - Science Faculty - Department of Biology, Turkey
Title Of Article
A study of calcium release from rat liver microsomes by thapsigargicin induction
شماره ركورد
34952
Abstract
The primary aim of the study was to test the influences of thapsigargicin in releasing Ca^2+ from the intracellular Ca^2+ stores and comparing it with the effects of thapsigargin. In this study, the effect of tumour promoter thapsigargicin on intracellular Ca2+ has been described. Therefore, rat liver endoplasmic reticulum subcellular fractions (microsomes) were employed and Ca^2+ movements measured by spectrofluorimeter. Fluo-3 studies were used to follow Ca^2+ release in experiments with microsomes. When results are evaluated, it has been concluded that like thapsigargin, thapsigargicin has the ability of discharging the intracellular Ca^2+ stores, increasing the intracellular free Ca^2+ concentration ([Ca^2+]i) and being a potent and specific inhibitor of the ER Ca^2+ -ATPase.
From Page
135
NaturalLanguageKeyword
Ca^2+ release , intracellular stores , SERCA ATPases , spectroscopy , thapsigargin (TG) , thapsigargicin (TGC)
JournalTitle
Veterinary Journal of Ankara University
To Page
140
JournalTitle
Veterinary Journal of Ankara University
Link To Document