Author/Authors :
KANIK, Emine Arzu Mersin Üniversitesi - Tıp Fakültesi - Bioistatistik ve Tıbbi Bilişim Anabilim Dalı, Turkey , TAŞDELEN, Bahar Mersin Üniversitesi - Tıp Fakültesi - Bioistatistik ve Tıbbi Bilişim Anabilim Dalı, Turkey , ERDOĞAN, Semra Mersin Üniversitesi - Tıp Fakültesi - Bioistatistik ve Tıbbi Bilişim Anabilim Dalı, Turkey
Title Of Article :
Randomization in Clinical Trials
Abstract :
The purpose of randomization in clinical trials is to assign patients into treatment groups randomly and to prevent “selection bias”. By using randomization methods, the patients can be assigned to groups so that they are similar to each other according to their participation criteria (homogenuous). However, in small samples, sampling distributions in groups may not be balanced or the patients may not be completely similar to each other in their demographical characters and their baseline clinical measurements. In this study, randomization methods which have solutions for this kind of limitations have been explained with some examples.
NaturalLanguageKeyword :
Randomization , Minimization , Clinical trial , Selection bias , Potential bias
JournalTitle :
Marmara Medical Journal
