Author/Authors :
KARA, Özlem Marmara Üniversitesi - Tıp Fakültesi, Eğitim ve Araştırma Hastanesi - Anestezi ve Reanimasyon Anabilim Dalı, Türkiye , UMUROGLU, Tümay Marmara Üniversitesi - Tıp Fakültesi, Eğitim ve Araştırma Hastanesi - Anestezi ve Reanimasyon Anabilim Dalı, Türkiye , GÜRSOY, Tolga Marmara Üniversitesi - Tıp Fakültesi, Eğitim ve Araştırma Hastanesi - Anestezi ve Reanimasyon Anabilim Dalı, Türkiye , SARAÇOĞLU, Kemal Tolga Marmara Üniversitesi - Tıp Fakültesi, Eğitim ve Araştırma Hastanesi - Anestezi ve Reanimasyon Anabilim Dalı, Türkiye , GOĞÜS, Fevzi Yılmaz Marmara Üniversitesi - Tıp Fakültesi, Eğitim ve Araştırma Hastanesi - Anestezi ve Reanimasyon Anabilim Dalı, Türkiye
Abstract :
Objectives: The aim of this study is to investigate the effects of different concentrations of albumin, which has antioxidant characteristics on renal antioxidant levels and renal functions in rats with sepsis. Materials and Methods: Twenty-eight adult male Sprague-Dawley rats were divided into 4 groups. No agent was implemented to Group K. Group S received 30 ml/kg of saline infusion for 90 min, Group A5 received 15 ml/kg of 5% albumin infusion for 90 min and Group A25 received 3 ml/kg of 25% albumin infusion for 45 min. At the end of the 18th hour, bilateral nephrectomy was performed. Blood samples were taken to determine blood urea nitrogen, creatinine and albumin levels. Kidney tissue samples were dissected to measure the levels of free oxygen radicals and antioxidants. Results: Better renal function, higher levels of glutathione and malondialdehyde with lower myeloperoxidase levels were obtained in septic rats following treatment with 2 different concentrations of albumin. In Group A25, blood urea nitrogen and renal glutathione levels were significantly higher than in Group A5. Conclusion: We are of the opinion that the rapid infusion of 25% albumin may prevent or delay the occurrence of renal dysfunction in patients with sepsis.
NaturalLanguageKeyword :
Sepsis , Albumin , Oxygen radicals , Antioxidants
