Author/Authors
Demiralay, Ebru Çubuk Süleyman Demirel University - Science Literature Faculty - Department of Chemistry, Turkey , Yılmaz, Hülya Süleyman Demirel University - Science Literature Faculty - Department of Chemistry, Turkey
Title Of Article
Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures
شماره ركورد
35962
Abstract
Ionization constant (pKa) is one among the parameter to be estimated with accuracy, irrespective of solubility constraints. In the present study, acid-base behaviour of the piroxicam and tenoxicam was studied. By using the potentiometric method, pKa values of piroxicam and tenoxicam have been determined in different percentage of acetonitrile-water binary mixtures (acetonitrile content between 30 and 45% in volume). Aqueous pKa values of these compounds were calculated by mole fraction and Yasuda-Shedlovsky equations. The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages.
From Page
34
NaturalLanguageKeyword
Potentiometric titrations , Acetonitrile , pKa , Yasuda , Shedlovsky Equation
JournalTitle
Süleyman Demirel University Faculty of Arts and Science Journal of Science
To Page
44
JournalTitle
Süleyman Demirel University Faculty of Arts and Science Journal of Science
Link To Document