Author/Authors :
Demiralay, Ebru Çubuk Süleyman Demirel University - Science Literature Faculty - Department of Chemistry, Turkey , Yılmaz, Hülya Süleyman Demirel University - Science Literature Faculty - Department of Chemistry, Turkey
Title Of Article :
Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures
Abstract :
Ionization constant (pKa) is one among the parameter to be estimated with accuracy, irrespective of solubility constraints. In the present study, acid-base behaviour of the piroxicam and tenoxicam was studied. By using the potentiometric method, pKa values of piroxicam and tenoxicam have been determined in different percentage of acetonitrile-water binary mixtures (acetonitrile content between 30 and 45% in volume). Aqueous pKa values of these compounds were calculated by mole fraction and Yasuda-Shedlovsky equations. The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages.
NaturalLanguageKeyword :
Potentiometric titrations , Acetonitrile , pKa , Yasuda , Shedlovsky Equation
JournalTitle :
Süleyman Demirel University Faculty of Arts and Science Journal of Science
