Görgün, Emine Pirim Cumhuriyet University - Faculty of Dentistry - Deptartment of Periodontology, Turkey , Toker, Hülya Cumhuriyet University - Faculty of Dentistry - Deptartment of Periodontology, Turkey , Korkmaz, Ertan Mahir Cumhuriyet University - Faculty of Science - Department of Moleculer Biology and Genetics, Turkey , Aydemir, Habeş Bilal Gaziosmanpaşa University - Faculty of Science - Department of Molecular Biology and Genetics, Turkey

Association of NF-κB gene polymorphism with aggressive and chronic periodontitis

37751

Objectives: Transcription factor nuclear factor-kappa B (NF-κB) is involved in the immune response against infection by a wide variety of cytokines and also plays a key role in gene expression. The aim of this study was to evaluate the gene polymorphism of NF-κB1(-94ins/del) in patients with chronic and aggressive periodontitis. Materials and Methods: 188 subjects, 75 AgP patients, 72 chronic periodontitis patients and 41 periodontally healty subjects, were included in our study. Blood samples were obtained from all subjects and DNA was isolated. Polymorphisms in NF-κB1(-94ins/del) were determined by polimeraz chain reaction- restriction fragment length polymorphism metod. Results: There was no significant difference in terms of age and gender among periodontitis patients enrolled in the study group and the control group (p 0.05). Genotype distribution and allele frequencies of NF-κB1 gene in AgP and KP groups showed no significant difference in comparison with the control group (p 0.05). Conclusions: Within the limits of this study, there was no association between NF-κB1 (-94 ins / del) promoter polymorphism and periodontal disease.

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Aggressive periodontitis , Chronic periodontitis , NF , κB , Gene polymorphisms ,

Cumhuriyet Dental Journal

397