Author/Authors :
Ökten, Gülsen Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Tıbbi Genetik Bilim Dalı, Turkey , Kara, Nurten Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Tıbbi Genetik Bilim Dalı, Turkey , Tural, Şengül Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Tıbbi Genetik Bilim Dalı, Turkey , Güneş, Sezgin Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Tıbbi Genetik Bilim Dalı, Turkey , Güven, Davut Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Koçak, İdris Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Balcı, Alaattin Samsun Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Turkey
Abstract :
Approximately 15-20% of all clinically recognized pregnancies are spontaneously aborted at different weeks. Rates of abnormal karyotypes were 50-60% in abortus material. In this retrospective study, we have investigated the chromosomal anomalies in abortus materials which referred to our labotatuary. One hundred and ten abortus material which were mostly first trimester were investigated between 2000-2009 years in Samsun and around. Karyotyping was performed on tissue culture and G-banded performed to chromosomes. In cytogenetic analysis of abortus material 83 (75.5%) revealed normal karyotype, 12 (11%) aneuploidy, 6 (5.4%) mosaic, 4 (3.6%) polyploidy, 2 (1.8%) mosaic polyploidy, 2 (1.8%) traslocation and 1 (0.9%) inversion. This study is important because this is the first study in Black Sea region and the first data of chromosome anomaly frequency in abortus material in this region. Cytogenetic investigation of abortus material and then to give a genetic counseling to the family will provide an attention for following pregnancies.
NaturalLanguageKeyword :
Abortus material , Tissue culture , Chromosome analysis , Cytogenetic , Recurrent abortus , Chromosomal anomaly
