Acar, Betül Kırıkkale University - Faculty of Medicine - Department of Neurology, Turkey , Dağ, Ersel Kırıkkale University - Faculty of Medicine - Department of Neurology, Turkey , Türkel, Yakup Kırıkkale University - Faculty of Medicine - Department of Neurology, Turkey

Lamotrigine induced seizures in juvenile myoclonic epilepsy

37999

Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome. Before the development of the new antiepileptic drugs (AEDs) after the 1990s, Valproate (VPA) was the first-line treatment in juvenile myoclonic epilepsy. However, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. Lamotrigine (LTG), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. We report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (GTC) seizures after decreasing the lose of VPA and initiating LTG.

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Antiepileptic drug , Seizure , Juvenile myoclonic epilepsy , Lamotrigine

Journal Of Experimental an‎d Clinical Medicine

208