Salış, Osman Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya Anabilim Dalı, Turkey , Bedir, Abdülkerim Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya Anabilim Dalı, Turkey , Alaçam, Hasan Ondokuz Mayıs Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya Anabilim Dalı, Turkey

Association of Ndrg-1 with cancer and iron chelators

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Human N-myc downstream-regulated gene 1 (Ndrg-1) has been first identified in Charhot-Marie-Tooth Disease type 4D (CMT4D). Recently, its association with cell differentiation, suppression of growth and proliferation, neoplasia, tumor progression and metastasis has been demonstrated. Ndrg-1 gene appears to be regulated in a variety of ways in different types of cancers. It is down-regulated in breast, prostate and colon cancers whereas it is up-regulated in hepatic cancers. Different and complex mechanisms may play a role in different types of cells in regulation of Ndrg-1 gene. These complex regulations includes major pathways in transcriptional, post-transcriptional and translational levels. It has been shown that desferrioxamine (DFO) and other chelators are effective anti-tumor agents. It’s possible that this effect of chelators is related to Ndrg-1 mRNA transcription, but it remains unknown which mechanism mediates this regulation and iron’s role in gene expression and proliferation and Ndrg-1 need further investigations.

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Iron , Desferrioxamine , Differentiation , HIF , 1 , Cancer , Ndrg , 1

Journal Of Experimental an‎d Clinical Medicine

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