Author/Authors :
çadirci, sertaç istanbul teknik üniversitesi - makine fakültesi - makine mühendisliği bölümü, İstanbul, turkey , demir, ufuk istanbul teknik üniversitesi - makine fakültesi - makine mühendisliği bölümü, İstanbul, Turkey , birol, semra zuhal istanbul teknik üniversitesi - nano-bilim ve nano-mühendislik bölümü, İstanbul, turkey , trabzon, levent istanbul teknik üniversitesi - nano-bilim ve nano-mühendislik bölümü, İstanbul, TURKEY , güneş, hasan istanbul teknik üniversitesi - makine fakültesi - makine mühendisliği bölümü, İstanbul, Turkey
Abstract :
In this study, wall shear stress and pressure difference values for a pure water flow in various microchannel configurations are obtained numerically. Through simulations, physical effects of various flow rates on endothelium and immune system cells are predicted and case studies are carried out to investigate the behavior of such cells under similar laboratory conditions. In-vivo physiological behavior of endothelium and monocyte cells under real conditions can be predicted by pressure differences and wall shear stresses calculated for various flowrates. In this concept, various microchannel configurations such as sudden expanding microchannels with different expansion ratios, microchannels with cavities on one side and symmetrically curved microchannels are designed and CFD simulations are carried out to obtain computational values of the pressure drops between the inlet and outlet of the microchannels as well as wall shear stress distributions on the bottom walls of the configurations.
NaturalLanguageKeyword :
Microchannel flows , Computational Fluid Dynamics (CFD) , Mechano , biological behavior , Wall shear stress
