Author/Authors
uslu, hamit university of kafkas - atatürk vocational school of health services - department of health care services, Kars, TURKEY , atýla uslu, gözde university of kafkas - faculty of veterinary - department of physiology, Kars, TURKEY , adali, yasemen university of çanakkale onsekiz mart - faculty of medicine - department of pathology, Çanakkale, TURKEY , makav, mustafa university of kafkas - faculty of veterinary - department of physiology, Kars, TURKEY , gelen, volkan university of kafkas - faculty of veterinary - department of physiology, Kars, TURKEY
Title Of Article
Protective Effects of Melatonin against Chronic Sodium Nitrite Exposure in Rats
شماره ركورد
41907
Abstract
In this study, anti-inflammatory effects melatonin (Mel) on liver and kidney damage induced by sodium nitrite (NaNO_2) used as a food additive were investigated. The study groups were control group (C), NaNO_2 group (NaNO_2) and melatonin + NaNO_2 group (Mel + NaNO_2). The first group received dimethyl sulfoxide (DMSO) and the second and third groups received NaNO_2 orally for twelve weeks. The third group received melatonin 2 hours before the administration of NaNO_2. Administration of NaNO_2 (80 mg/kg/day) for 12 weeks orally to rats increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) (P 0.001) and urea (P 0.01) levels. Interleukin 1-alpha (IL-1α) (P 0.05) and tumor necrosis factor alpha (TNF-α) (P 0.01, P 0.001 respectively) levels were found to be increased in NaNO_2 group in liver and kidney homogenates. It was also determined that IL-6 (P 0.001) levels were increased in kidney tissue. On the other hand, it was also found that there was a decrease at the levels of serum AST (P 0.001), ALT, urea (P 0.05), liver IL-1α, TNF-α (P 0.01), and kidney TNF-α, IL-6 (P 0.05) in group given melatonin (500 μg/kg/day) 2 hours before NaNO_2. In addition, it was observed that there was less liver and kidney damage than NaNO_2 group in the pathological examinations Mel + NaNO_2 applied group. The present data demonstrate that melatonin administration has visible modulatory effects and can eliminate inflammation; moreover, it can prevent the increase in biochemical markers caused by chronic sodium nitrite administration.
From Page
139
NaturalLanguageKeyword
Melatonin , sodium nitrite , food additive , inflammation
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
To Page
145
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
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