Author/Authors
KUTLU, Mehtap Anadolu Üniversitesi - Fen Fakültesi - Biyoloji Bölümü, Turkey , ÖZTAS, Esin Anadolu Üniversitesi - Fen Fakültesi - Biyoloji Bölümü, Turkey , AYDOGAN, Gözde Anadolu Üniversitesi - Fen Fakültesi - Biyoloji Bölümü, Turkey , ISIKDAG, Ilhan Anadolu Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey , ÖZKAY, Yusuf Anadolu Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey
Title Of Article
AN INVESTIGATION OF MUTAGENIC ACTIVITIES OF SOME 9- SUBSTITUED-PHENANTHRENE DERIVATIVES WITH AMES / SALMONELLA / MICROSOME TEST
شماره ركورد
41956
Abstract
In this study, three different 9-Substituted phenantrene derivatives that were synthesized to be used as basic matter for drugs were tested for their mutagenic potency in strains TA 98 and TA 100 of Salmonella typhimurium by using Ames test. Therefore, both strains were tested in the absence or presence of S9 metabolic activation, for five different doses of each test substances in two paralel independent experiments. In the absence of metabolic activation, while only one of the compounds were causing frame-shift mutations, two of them were determined to induce base pair substitution mutations.In the presence of metabolic activation, while two of the compounds were mutagenic for TA 98, base pair substitution mutations were not detected for any of the substances. Each of the compounds tested were found to be mutagenic for at least one strain in the presence or absence of S9.
From Page
83
NaturalLanguageKeyword
Ames test , Phenanthrene derivatives , Mutagenecity
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
94
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document