Author/Authors
KOÇYIGIT-KAYMAKÇIOGLU, Bedia Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , ORUÇ-EMRE, Elçin E. Gaziantep University - Faculty of Arts and Sciences - Department of Chemistry, Turkey , BEYHAN, Nagihan Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , TOKLU, Hale Z. Marmara University - Faculty of Pharmacy - Department of Pharmacology, Turkey , GÜMRÜ, Salih Marmara University - Faculty of Pharmacy - Department of Pharmacology, Turkey , ARICIOGLU, Feyza Marmara University - Faculty of Pharmacy - Department of Pharmacology, Turkey
Title Of Article
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES
شماره ركورد
41962
Abstract
In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, 1H-NMR, mass spectral data and elemental analysis. These synthesized 2-pyrazoline compounds have been tested in vivo anticonvulsant activity by using pentylenetetrazole (PTZ) induced seizure and maximal electroshock (MES) seizure tests at a dose of 50 mg/kg. None of the compounds have in vivo anticonvulsant properties in PTZ test whereas some compounds showed in vivo anticonvulsant activity in MES test. Therefore, 2-pyrazoline compounds have a promising in vivo anticonvulsant activity especially on generalized absence seizures.
From Page
137
NaturalLanguageKeyword
Chalcones , 2 , Pyrazolines , Thiocarbamide , Anticonvulsant activity
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
144
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
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