Prognostic Importance of p53 Expression in Patients with Localized Gastric Cancer Who Had Adjuvant Chemoradiotherapy

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Objective: The postopreative standard therapy in gastric cancer is 5FU based chemotherapy and concurrent 45 Gy external radiothearpy , nowadays. The high rates of toxicity of this thearpy causes discontiniuty in majority of the patients. These side effects can be prevented by predicting the response to therapy by the help of some spesisfic clinical and laboratory parameters determined at the time of diagnosis. In our study the prognostic and -if there is - the predictive role of p53 expression in patients with gastric cancer who had adjuvant chemotherapy has been searched. Material and Methods: Patients with a postoperative histopathologic diagnosis and who had adjuvant chemoradiotherapy in Medical Oncology and local Radiation Oncology Departments of Antalya Eucation and Research Hospital between 2008-2011 were enrolled in this study. p53 expression was searched by immunohistochemical method. Results: A total of 20 patients , (11 (%52,4) male and 9 (%42,9) female) were enrolled in the study. p53 expression was found positive in 13 (%61,9) patients and negative in 7 (%33,3)patients. Median survival time ws found 12.2 months in p53 negaive patients and 11 months in p53 positive patients. A significant relationship was not found between p53 expression and survival. (P:0,781). Conclucion: Although we were not able to show the predictive role of p53 expression in this patient group in this study, we think that new studies including determining p53 in blood samples will be helpful in explaining some unknown things about this issue.

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Gastric cancer , chemoradiotherapy , p53

Kocatepe Medical Journal

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Kocatepe Medical Journal