Investigation of Aspirin Resistance of Frequency in Patients with Coronary Artery Disease by Using PFA-100 System

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Objective: Today aspirin is the most widely used antithrombotic drug. In this study frequency of the aspirin resistance (AR) was evaluated in coronary artery disease (CAD) patients with PFA-100 system. Material and Methods: In the study 97 patients that routinely used 100 mg or higher aspirin for four weeks and that had coronary angiographic examination were included. In the cases with PFA-100 system AR was determined. Results: When all the cases were examined for AR, it was more frequent in the cases with CAD. In the group with CAD, patients with AR more frequently smoked smoking and the LDL and Total Cholesterol/HDL cholesterol levels were significantly higher compared to the aspirin sensitive patients. When the cases with CAD were compared according to the aspirin dose they had (100mg ve 300mg) the two groups did not differ significantly. The patients with CAD were divided into three goups accordıng to the number of dıseased vessels. Group 1 was constituted of cases with one vessel disease (n=21, % 35), group 2 two vessel disease (n=16, % 26) and group 3 was constituted of patients with three vessel disease (n=23, % 38). There no was statistically significant difference in terms of AR among all three groups. Conclusion: As a result, it was shown that the responses were not the same in patients taking aspirin. It was concluded that in cases with CAD adequacy of aspirin response may be quickly evaluated by PFA-100 system and the therapy may be adjusted according to the results.

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Coronary artery disease , aspirin resistance , PFA , 100 system

Kocatepe Medical Journal

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Kocatepe Medical Journal