Author/Authors
DİRİCAN, Ahmet Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , KÜÇÜKZEYBEK, Yüksel Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , AYDIN, Ayhan Izmir Katip Celebi University - Ataturk Training and Research Hospital, Radiation Oncology Clinic, Turkey , DEMİR, Lutfiye Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , CAN, Alper Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , BAYOGLU, İbrahim Vedat Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , AKYOl, Murat Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , YURTSEVEN, Samim Izmir Katip Celebi University - Ataturk Training and Research Hospital, Radiation Oncology Clinic, Turkey , SOMALİ, İsil Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , ERTEN, Ciğdem Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , ALACACIOĞLU, Ahmet Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey , CAKALAGOĞLU UNAY, Fulya Izmir Katip Celebi University - Ataturk Training and Research Hospital, Pathology Clinic, Turkey , TARHAN, Mustafa Oktay Izmir Katip Celebi University - Ataturk Training and Research Hospital, Medical Oncology Clinic, Turkey
Title Of Article
Induction or Adjuvant Docetaxel/ Cisplatin Chemotherapy in Advanced Stage Non-Metastatic Nasopharyngeal Cancer
شماره ركورد
42133
Abstract
Objective: Meta-analyses of randomized controlled trials was to determine the additional value of induction, concurrent, and/or adjuvant chemotherapy to radiation in the treatment of locally advanced nasopharyngeal carcinoma (NPC) with regard to the overall survival (OS) Material and Methods: A total of 28 patients with loacally advanced NPC were included for this trial. Docetaxel (75 mg/m2 on Day 1) and cisplatin (75 mg/m2 on Day 1) were administered every 21 days, after or before which concurrent chemoradiotherapy (CCRT) was administered. The efficiency of the adjuvant or inductional docetaxel/cisplatin regime and the toxicity profile were retrospectively evaluated Results: The objective response rate (ORR) was 75 % (13 partial responses, 8 complete responses). Stable disease (SD) was seen in 7 patients (25 %) whereas there was no progressive disease (PD). The median PFS for the induction chemoterapy group was 18.7 months and had not been reached for the adjuvant chemoterapy group. The 3-year PFS rates were 20 % and 66,9 %, respectively (p:0.79). The median OS for the induction chemoterapy group was 25.36 months and had not been reached for the adjuvant chemoterapy group. The 3-year OS rate was 26,7 % and 72,2 %, respectively (p:0.231). Conclusion: In our study we demonstrated that the addition of adjuvant chemotherapy to CCRT did not additional benefit compared to hystorical data. Further studies are required to invastigate this hypothesis.r
From Page
92
NaturalLanguageKeyword
Chemotherapy , adjuvant and induction chemotherapy , nasopharyngeal neoplasms
JournalTitle
Kocatepe Medical Journal
To Page
98
JournalTitle
Kocatepe Medical Journal
Link To Document