Author/Authors
ÇELİK, Sefa Afyon Kocatepe Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya A D, Turkey , ŞEN, Serkan Afyon Kocatepe Üniversitesi - Atatürk Sağlık Hizmetleri MYO, Turkey , HAZMAN, Ömer Afyon Kocatepe Üniversitesi - Fen Edebiyat Fakültesi - Kimya Bölümü, Turkey
Title Of Article
Cellular Pathways In Endoplasmic Reticulum Stress And The Role Of Beta Cell Apoptosis Induced By Endoplasmic Reticulum Stress In The Pathogenesis Of Type II Diabetes
شماره ركورد
42222
Abstract
It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptosis is important owing to eradicate the damaged or harmful cells without inflammation in various biological facts. This process is also important for homeostasis of organism. B cells are often exposed to ER stress due to excess insulin secretion. In recent years, it was showed that endoplasmic reticulum was an important organelle in apoptotic signal conduction. Investigations including apoptosis induced ER stress will supply new approaches in to clarify the new mechanisms in diabetic pathogenesis and new treatment strategies in diabetes.
From Page
227
NaturalLanguageKeyword
Tip 2 Diabetes , Endoplasmic reticulum stress , Apoptosis
JournalTitle
Kocatepe Medical Journal
To Page
237
JournalTitle
Kocatepe Medical Journal
Link To Document