THE INVESTIGATION OF TANNIC ACID EFFECTS ON REMOVAL OF HEAVY METALS AND SOME BIOCHEMICAL VALUES IN THE RAT TOXICITY INDUCED BY CADMIUM

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OBJECTIVE: Cadmium (Cd), one of the major environmentalpollutants used intensively in the industrial field and could causesa variety of vital threats due to our exposure in our dailylives. Having a long half-life, Cd causes direct or indirect toxicityto respiratory, urinary, cardiovascular, gastrointestinal, nervoussystem and bones. It is known that Cd that accumulates in thebody causes many diseases such as osteoporosis, anemia, eosinophilia,anosmia and chronic rhinitis. In our study, we aimedto investigate the role of tannic acid (TA), an antioxidant substancewith a high content of flavonoids and heavy metal chelatingagents, in order to investigate its role in protecting fromCd toxicity.MATERIALS AND METHODS: In this study, it was used 28Spraque-Dawley, 200-300 gr, 3-4 monthly male rats. For pre-treatment,TA (50 mg/kg/day) was administered by intraperitoneal(i.p) injection to the experimental groups for 5 days. And thena single dose CdCl2 (35 mg/kg) was was administered by intragastric(i.g).RESULTS: It was observed that superoxide dismutase (SOD)values decreased in hemolysate, liver and kidney by CdCl2 administration;but increased with TA. Malondialdehyde (MDA)values increased with CdCl2 administration whereas decreasedwith TA the hemolysate and liver. TA was found to be effectivein decreasing heart accumulation, while TA was not effectivein reducing accumulation with CdCl2 administration in liver,kidney, lung, testis and spleen. TA is not effective in reducingincreased iron accumulation with CdCl2 administration in thekidney, spleen and heart, but in liver, lung and testis it couldbe effective.CONCLUSIONS: Food and drinks used in the daily diet mayincrease the quality of life of individuals by early prevention ofcertain diseases that may result in exposure to toxic agents. Inour study, it has been shown that TA, which is consumed in ourdaily lives, may be effective in protecting substances from heavymetal toxicity. According to the results obtained, differentresults could be reached in different tissues; but when assessedin general, the harmful effects of Cd, or at least the result thatTA have been achieved to reduce the accumulation of some tissues.

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Cadmium , Tannic Acid , Toxicity , Rat

Kocatepe Medical Journal

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Kocatepe Medical Journal