Author/Authors
büker, eda gazi university - faculty of pharmacy - department of basic pharmaceutical science, Ankara, Turkey , yaşar, nagihan ankara university - faculty of pharmacy - department of analytical chemistry, Ankara, Turkey , dinç, erdal ankara university - faculty of pharmacy - department of analytical chemistry, Ankara, Turkey
Title Of Article
SIMULTANEOUS QUANTITATIVE ANALYSIS OF TWO ANTHELMINTIC DRUGS IN A VETERINARY DOSAGE FORM
شماره ركورد
44713
Abstract
In this research article, a new chromatographic method ultra-performance liquid chromatography (UPLC) method was developed for the quantification of ivermectin (IMT)-preziquantel (PRZQ) in a two-component mixture and veterinary dosage form mixture. The separation of the studied veterinary drugs (IMT and PRZQ) was carried out on Waters Acquity ® BEH C18 column (50mm x 2.1 mm i.d., 1.7 m) using a mobile phase consisting of water-acetonitrile-methanol (10:70:20, v/v). In the chromatographic analysis, flow rate was 0.38 mL/min, and column temperature was maintained at 42 0C. The chromatographic detection of IMT and PRZQ was made at the wavelength of 220.0 and 245.0 nm, respectively. The developed UPLC method was validated and applied to real samples consisting of IMT and PRZQ. Recovery assay results were found to be 100.4 % for PRZQ and 101.8 % for IMT. The presented UPLC method is introduced as an alternative choice for the quality control of pharmaceutical preparations containing these drugs. For the quality control of pharmaceutical preparations containing these drugs, the presented UPLC method is introduced as an alternative experimental analysis choice.
From Page
22
NaturalLanguageKeyword
Ultra performance liquid chromatography , Ivermectin , praziquantel , Anthelmintic veterinary dosage form
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
To Page
30
JournalTitle
Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology
Link To Document