Calculating endocardial potentials from epicardial potentials measured during external stimulation

Author

Wolf, Patrick D. ; Tang, Anthony S L ; Ideker, Raymond E. ; Pilkington, Theo C.

Author_Institution

Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA

Volume

39

Issue

9

fYear

1992

Firstpage

913

Lastpage

920

Abstract

A boundary integral method for calculating the potential field generated by external stimulation at locations within the heart using realistic heart geometry and samples of the potential taken from the epicardial surface is presented. This method assumes the heart is homogeneous and isotropic. To test the method epicardial and endocardial measurements are made in dogs during transthoracic pacing stimuli. From the epicardial potential measurements the endocardial potential values are predicted and compared with the measured data. Despite the seemingly gross assumptions, the mean correlation coefficient between the measured and predicted potentials for three dogs and eleven stimulation electrode configurations was 0.985, and the mean rms error was 17%.

Keywords

bioelectric potentials; electrocardiography; boundary integral method; correlation coefficient; dogs; electrode configurations; endocardial potentials calculation; epicardial potentials; epicardial surface; external stimulation; mean rms error; realistic heart geometry; transthoracic pacing stimuli; Anisotropic magnetoresistance; Biomedical electrodes; Biomedical engineering; Biomedical measurements; Defibrillation; Dogs; Heart; Integral equations; Testing; Voltage; Action Potentials; Animals; Bias (Epidemiology); Cardiac Pacing, Artificial; Dogs; Electric Stimulation; Endocardium; Evaluation Studies as Topic; Heart Conduction System; Models, Cardiovascular; Models, Neurological; Pericardium; Regression Analysis;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.256424

Filename

256424