Title :
Label-Free Fiber Optic Biosensors With Enhanced Sensitivity
Author :
Yang, Jian ; Sandhu, Pawan ; Liang, Wanguo ; Xu, Chang-Qing ; Li, Yingfu
Author_Institution :
McMaster Univ., Hamilton
Abstract :
A sensitivity-enhanced long-period grating in-fiber Michelson interferometer with diameter-reduced cladding was proposed for the first time, and was also demonstrated as a label-free biosensor based on refractive index measurement. The cladding structure dependence of the sensitivity for antibody-antigen immuno-sensing was studied experimentally. The proposed biosensor has shown an 8.5-fold sensitivity enhancement as compared to sensors without cladding reduction.
Keywords :
Michelson interferometers; biosensors; fibre optic sensors; optical fibre cladding; refractive index; refractive index measurement; antibody-antigen immuno-sensing; diameter-reduced cladding; fiber optic biosensors; long-period grating in-fiber Michelson interferometer; refractive index measurement; Biosensors; Gratings; Immune system; Interference; Optical fibers; Optical films; Optical interferometry; Optical refraction; Refractive index; Transducers; Biomedical transducers; Michelson interferometers; optical fiber gratings; optical fiber transducers;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2007.910999
