DocumentCode
1012174
Title
Label-Free Fiber Optic Biosensors With Enhanced Sensitivity
Author
Yang, Jian ; Sandhu, Pawan ; Liang, Wanguo ; Xu, Chang-Qing ; Li, Yingfu
Author_Institution
McMaster Univ., Hamilton
Volume
13
Issue
6
fYear
2007
Firstpage
1691
Lastpage
1696
Abstract
A sensitivity-enhanced long-period grating in-fiber Michelson interferometer with diameter-reduced cladding was proposed for the first time, and was also demonstrated as a label-free biosensor based on refractive index measurement. The cladding structure dependence of the sensitivity for antibody-antigen immuno-sensing was studied experimentally. The proposed biosensor has shown an 8.5-fold sensitivity enhancement as compared to sensors without cladding reduction.
Keywords
Michelson interferometers; biosensors; fibre optic sensors; optical fibre cladding; refractive index; refractive index measurement; antibody-antigen immuno-sensing; diameter-reduced cladding; fiber optic biosensors; long-period grating in-fiber Michelson interferometer; refractive index measurement; Biosensors; Gratings; Immune system; Interference; Optical fibers; Optical films; Optical interferometry; Optical refraction; Refractive index; Transducers; Biomedical transducers; Michelson interferometers; optical fiber gratings; optical fiber transducers;
fLanguage
English
Journal_Title
Selected Topics in Quantum Electronics, IEEE Journal of
Publisher
ieee
ISSN
1077-260X
Type
jour
DOI
10.1109/JSTQE.2007.910999
Filename
4404849
Link To Document