Title :
Integrated patch-clamp biosensor for high-density screening of cell conductance
Author :
Weerakoon, P. ; Sigworth, F. ; Culurciello, E.
Author_Institution :
Dept. of Electr. Eng., Yale Univ., New Haven, CT
Abstract :
The first fully integrated implementation of a patch-clamp measurement system is presented. The system was implemented in a 0.5 mum silicon-on-sapphire process. The system can record cell membrane currents up to plusmn 20 nA, with an rms noise of 5 pA at 10 kHz bandwidth. The system can compensate for the capacitance and resistance of the pipette electrode, up to 20 pF and 4 MOmega, respectively. The die size is 1150 by 700 mum. The power consumption is 3.3 mW at 3.3 V.
Keywords :
bioelectric phenomena; biomembranes; biosensors; cellular biophysics; electric resistance; capacitance; cell conductance; cell membrane currents; high density screening; patch clamp biosensor; pipette electrode; power 3.3 MW; resistance; silicon-on-sapphire process; size 1150 mum; size 700 mum; voltage 3.3 V;
Journal_Title :
Electronics Letters
DOI :
10.1049/el:20083151
