Investigation of the effects of microbubble shell disruption on population scattering and implications for modeling contrast agent behavior

Author

Ting Chin, Chien ; Burns, Peter N.

Author_Institution

Dept. of Med. Biophys., Toronto Univ., Ont., Canada

Volume

51

Issue

3

fYear

2004

fDate

3/1/2004 12:00:00 AM

Firstpage

286

Lastpage

292

Abstract

In a previous study, quantitative measurement of nonlinear scattering revealed some quantitative discrepancies with a model for ultrasound scattering by a population ensemble of microbubbles. This study is designed to investigate the effect of the shell on single-pulse scattering by a population of contrast microbubbles. Nonlinear scattering was measured shortly (15 /spl mu/s) after exposure to a previous ultrasound pulse with variable intensity. The short time delay eliminated the influence of gas diffusion and focused the study on the consequence of ultrasound exposure. The results suggest that single-pulse scattering is dependent on the disruption properties of the bubble shell and confirm the significance of the shell properties.

Keywords

bubbles; nonlinear acoustics; ultrasonic measurement; ultrasonic scattering; gas diffusion; microbubble shell disruption; nonlinear scattering; population scattering; short time delay; single pulse scattering; ultrasound pulse; ultrasound scattering; Acoustic measurements; Acoustic scattering; Biomedical acoustics; Biophysics; Delay effects; Predictive models; Pulse measurements; Time domain analysis; Ultrasonic imaging; Ultrasonic variables measurement; Contrast Media; Dose-Response Relationship, Radiation; Energy Transfer; Materials Testing; Microbubbles; Models, Chemical; Scattering, Radiation; Sonication; Ultrasonics; Ultrasonography;

fLanguage

English

Journal_Title

Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on

Publisher

ieee

ISSN

0885-3010

Type

jour

DOI

10.1109/TUFFC.2004.1320784

Filename

1320784