Title :
Smart Microrobots for Mechanical Cell Characterization and Cell Convoying
Author :
Boukallel, M.. ; Gauthier, M. ; Dauge, M.. ; Piat, E.. ; Abadie, J..
Author_Institution :
Robotics Lab. of Paris, Paris
Abstract :
This paper deals with the effective design of smart microrobots for both mechanical cell characterization and cell convoying for in vitro fertilization. The first microrobotic device was developed to evaluate oocyte mechanical behavior in order to sort oocytes. A multi-axial micro-force sensor based on a frictionless magnetic bearing was developed. The second microrobotic device presented is a cell convoying device consisting of a wireless micropusher based on magnetic actuation. As wireless capabilities are supported by this microrobotic system, no power supply connections to the micropusher are needed. Preliminary experiments have been performed regarding both cell transporting and biomechanical characterization capabilities under in vitro conditions on human oocytes so as to demonstrate the viability and effectiveness of the proposed setups.
Keywords :
bioMEMS; biomechanics; biomedical engineering; cellular transport; force sensors; intelligent actuators; microactuators; microrobots; biomechanical characterization; cell convoying; cell transporting; frictionless magnetic bearing; human oocytes; in vitro fertilization; magnetic actuation; mechanical cell characterization; multiaxial microforce sensor; smart microrobots; wireless micropusher; In vitro; In vitro fertilization; Intelligent sensors; Magnetic devices; Magnetic levitation; Magnetic sensors; Mechanical sensors; Power supplies; Sensor phenomena and characterization; Wireless sensor networks; Cell convoying; in vitro fertilization process; mechanical cell characterization; microrobotics; Biomechanics; Cell Culture Techniques; Cell Separation; Cells, Cultured; Equipment Design; Equipment Failure Analysis; Humans; Micromanipulation; Miniaturization; Oocytes; Physical Stimulation; Robotics;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2007.891171