Title :
Harmonic Analysis of Neuronal Membranes and Tissue Using SQUIDs
Author :
Claycomb, James R. ; Tran, Quoc ; Vajrala, Vijayanand ; Miller, John H., Jr.
fDate :
6/1/2009 12:00:00 AM
Abstract :
We report the nonlinear response of tissue and nerve fibers in the earthworm Lumbricus terrestris to sinusoidal electric field excitations. A High-T c Superconducting Quantum Interference Device (SQUID) magnetometer detects the magnetic field generated by complex currents in the animal. SQUID signals are processed on a Fast Fourier Transform (FFT) spectrum analyser. Use of the SQUID eliminates low frequency polarization impedance and field distortion that would be present near pickup electrodes. Electrical 4-probe harmonic response measurements of the excised nerve fiber are then compared to the driven Hodgkin-Huxley active transport model.
Keywords :
bioelectric phenomena; biological techniques; biological tissues; biomembrane transport; cellular biophysics; fast Fourier transforms; harmonic analysis; Fast Fourier transform spectrum analyser; Hodgkin-Huxley active transport model; SQUID magnetometer; earthworm Lumbricus terrestris; electrical 4-probe harmonic response measurements; high-temperature superconducting quantum interference device; nerve fibers; neuronal membranes; nonlinear harmonic analysis; sinusoidal electric field excitations; tissue fibers; Hodgkin-Huxley equations; NLDS; SQUIDs; neuronal membranes; nonlinear dielectric spectroscopy; nonlinear harmonic analysis;
Journal_Title :
Applied Superconductivity, IEEE Transactions on
DOI :
10.1109/TASC.2009.2018818
