Title :
Transdermal drug delivery by localized intervention
Author :
Gowrishankar, T.R. ; Herndon, Terry O. ; Weaver, James C.
Abstract :
Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free manner. These openings are similar in dimension to commonly experienced scratches and nicks on the skin. These localized openings provide pathways for sustained delivery of drugs either passively using a patch or actively using pressure or iontophoresis.
Keywords :
bioelectric phenomena; biomembrane transport; drug delivery systems; skin; buccal delivery; compound degradation; dermal microscissioning; gastrointestinal tract; injury protection; iontophoresis; localized intervention; pulmonary delivery; skin electroporation; transdermal drug delivery; transmucosal delivery; Biomembranes; Chemicals; Degradation; Drug delivery; Gastrointestinal tract; Insulation; Lipidomics; Minimally invasive surgery; Protection; Skin; Administration, Cutaneous; Drug Delivery Systems; Electrochemotherapy; Humans; Lidocaine; Micro-Electrical-Mechanical Systems; Microelectrodes; Microtechnology; Onychomycosis;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2008.931016
