VCSEL Optoelectronic Biosensor for Detection of Infectious Diseases

Author

Huang, Michael C Y ; Mateus, Carlos F R ; Foley, Jonathan E. ; Beatty, Robert ; Cunningham, Brian T. ; Chang-Hasnain, Connie J.

Author_Institution

California Univ., Berkeley

Volume

20

Issue

6

fYear

2008

fDate

3/15/2008 12:00:00 AM

Firstpage

443

Lastpage

445

Abstract

We report on the detection of human anti-dengue antibodies from serum samples using a compact optoelectronic label-free biosensor. The system consists of a tunable vertical-cavity surface-emitting laser, guided-mode resonant sensor surface, and two silicon pin detectors. This novel biosensor demonstrated sufficient sensitivity in a clinical-relevant assay, making it a potential new platform for simplified and rapid point-of-care diagnostic tests for the detection of infectious diseases.

Keywords

biomedical equipment; biomedical measurement; diseases; elemental semiconductors; laser applications in medicine; laser cavity resonators; p-i-n diodes; patient diagnosis; silicon; surface emitting lasers; VCSEL; clinical-relevant assay; disease detection; guided-mode resonant sensor surface; human antidengue antibodies; infectious diseases; label-free biosensor; optoelectronic biosensor; point-of-care diagnostic tests; serum samples; silicon pin detectors; tunable laser; vertical-cavity surface-emitting laser; Biosensors; Diseases; Humans; Resonance; Sensor systems; Silicon; Surface emitting lasers; Testing; Tunable circuits and devices; Vertical cavity surface emitting lasers; Biomedical transducer; medical diagnosis; vertical- cavity surface-emitting lasers (VCSELs);

fLanguage

English

Journal_Title

Photonics Technology Letters, IEEE

Publisher

ieee

ISSN

1041-1135

Type

jour

DOI

10.1109/LPT.2008.916947

Filename

4455662