Title :
VCSEL Optoelectronic Biosensor for Detection of Infectious Diseases
Author :
Huang, Michael C Y ; Mateus, Carlos F R ; Foley, Jonathan E. ; Beatty, Robert ; Cunningham, Brian T. ; Chang-Hasnain, Connie J.
Author_Institution :
California Univ., Berkeley
fDate :
3/15/2008 12:00:00 AM
Abstract :
We report on the detection of human anti-dengue antibodies from serum samples using a compact optoelectronic label-free biosensor. The system consists of a tunable vertical-cavity surface-emitting laser, guided-mode resonant sensor surface, and two silicon pin detectors. This novel biosensor demonstrated sufficient sensitivity in a clinical-relevant assay, making it a potential new platform for simplified and rapid point-of-care diagnostic tests for the detection of infectious diseases.
Keywords :
biomedical equipment; biomedical measurement; diseases; elemental semiconductors; laser applications in medicine; laser cavity resonators; p-i-n diodes; patient diagnosis; silicon; surface emitting lasers; VCSEL; clinical-relevant assay; disease detection; guided-mode resonant sensor surface; human antidengue antibodies; infectious diseases; label-free biosensor; optoelectronic biosensor; point-of-care diagnostic tests; serum samples; silicon pin detectors; tunable laser; vertical-cavity surface-emitting laser; Biosensors; Diseases; Humans; Resonance; Sensor systems; Silicon; Surface emitting lasers; Testing; Tunable circuits and devices; Vertical cavity surface emitting lasers; Biomedical transducer; medical diagnosis; vertical- cavity surface-emitting lasers (VCSELs);
Journal_Title :
Photonics Technology Letters, IEEE
DOI :
10.1109/LPT.2008.916947
