Optical measurement of nasal swellings

Author

Hampel, U. ; Schleicher, E. ; Wüstenberg, E.G. ; Hüttenbrink, K-B

Author_Institution

Inst. of Biomed. Eng., Univ. of Technol., Dresden, Germany

Volume

51

Issue

9

fYear

2004

Firstpage

1673

Lastpage

1679

Abstract

We introduce a new optical method to noninvasively and continuously measure the swelling process of the nasal mucosa whereby we use light of different wavelengths in the red and near-infrared range which is transilluminated through the nasal tissue and whose extinction is recorded as a function of time. From the temporal and spectral extinction data, we are able to extract characteristic parameters that describe the swelling process quantitatively by means of a regression-type parameter estimation algorithm. The method has been applied to the nasal allergen provocation test and verified on a limited number of volunteers.

Keywords

bio-optics; biological tissues; biomedical measurement; infrared spectra; optical sensors; parameter estimation; patient diagnosis; regression analysis; swelling; allergy diagnostics; nasal allergen provocation test; nasal mucosa Swellings; nasal tissue; near-infrared spectroscopy; optical method; optical sensor; regression-type parameter estimation algorithm; spectral extinction data; temporal extinction data; Acoustic measurements; Acoustic pulses; Acoustic testing; Biomedical engineering; Biomedical measurements; Electrical resistance measurement; Immune system; Optical sensors; Pulse measurements; Wavelength measurement; Adult; Diagnosis, Computer-Assisted; Edema; Equipment Design; Equipment Failure Analysis; Female; Humans; Male; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; Nose Diseases; Optics; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Infrared; Transducers;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2004.827939

Filename

1325828