In Vitro Analysis of Cisplatin Functionalized Magnetic Nanoparticles in Combined Cancer Chemotherapy and Electromagnetic Hyperthermia

Author

Babincova, M. ; Altanerova, V. ; Altaner, C. ; Bergemann, C. ; Babinec, P.

Author_Institution

Comenius Univ., Bratislava

Volume

7

Issue

1

fYear

2008

fDate

3/1/2008 12:00:00 AM

Firstpage

15

Lastpage

19

Abstract

A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.

Keywords

cancer; cellular biophysics; drug delivery systems; hyperthermia; iron compounds; magnetic particles; nanobiotechnology; nanoparticles; radiation therapy; BP6 rat sarcoma cells; FeO; cis-diamminedichloroplatinum(II); cisplatin functionalized magnetic nanoparticles; combined cancer chemotherapy; drug release; electromagnetic hyperthermia; iron oxide magnetic nanoparticles; Cancer; Control systems; Drugs; Electromagnetic heating; Heat treatment; Hyperthermia; In vitro; Iron; Nanoparticles; Temperature control; Cis-diamminedichloroplatinum(II) (cisplatin); combined hyperthermia; electromagnetic field; magnetic nanoparticles; minimally invasive therapy; targeted tumor cell killing; Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Combined Modality Therapy; Drug Carriers; Drug Therapy; Hyperthermia, Induced; Magnetics; Nanoparticles; Rats; Sarcoma; Treatment Outcome;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2008.2000145

Filename

4459708