Title :
Computational approach to systems biology: from fraction to integration and beyond
Author :
Dhar, Pawan K. ; Zhu, Hao ; Mishra, Santosh K.
Author_Institution :
Syst. Biol. Group, Bioinformatics Inst., Singapore
Abstract :
Systems biology is an approach to understanding the workings of whole biological systems. The various methods used for systems analyses range from experimental to computational. In this paper, we describe basic concepts of systems biology, modeling challenges that arise from the massively parallel interaction among components in biological systems, and what lies beyond integration of modular knowledge.
Keywords :
biology computing; cellular automata; physiological models; cellular automata; computational approach; fraction; integration; modeling; modular knowledge; systems analysis; systems biology; whole biological systems; Automata; Bioinformatics; Biological system modeling; Biological systems; Biology computing; Data engineering; Equations; Mathematical model; Systems biology; Throughput; Animals; Cell Physiology; Computational Biology; Computer Simulation; Gene Expression Regulation; Humans; Models, Biological; Signal Transduction; Systems Biology; Systems Integration;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2004.833699
