A New Instrument Designed to Measure the Magnetic Susceptibility of Human Liver Tissue In Vivo

Author

Farrell, D.E. ; Allen, C.J. ; Whilden, M.W. ; Kidane, T.K. ; Baig, T.N. ; Tripp, J.H. ; Brown, R.W. ; Sheth, S. ; Brittenham, G.M.

Author_Institution

Case Western Reserve Univ., Cleveland

Volume

43

Issue

9

fYear

2007

Firstpage

3543

Lastpage

3554

Abstract

All existing superconducting instrumentation for measuring the concentration of iron stored in the human liver requires liquid helium for its operation. We report the mathematical modeling, optimization, and instrumental performance of an instrument that uses high-transition-temperature (high-T_c) superconductors. Requiring only liquid nitrogen to operate, the susceptometer represents the first medical application of the phenomenon of high-temperature superconductivity with the potential for widespread clinical utility.

Keywords

biomedical equipment; chemical variables measurement; high-temperature superconductors; iron; liver; magnetic susceptibility; optimisation; Fe; high transition temperature superconductors; human liver tissue in vivo; iron concentration measurement; liquid helium; liquid nitrogen; magnetic susceptibility; medical application; optimization; superconducting instrumentation; susceptometer; Helium; High temperature superconductors; Humans; In vivo; Instruments; Iron; Liver; Magnetic susceptibility; Mathematical model; Nitrogen; Diamagnetic; hepatic iron concentration; high-temperature superconductivity; magnetic susceptibility; paramagnetic; phantom; storage iron; susceptometer;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2007.901352

Filename

4292289