Title :
Dynamics Modeling and Control of Electroporation-Mediated Gene Delivery
Author :
Ma, Ou ; Zhang, Mingjun
Author_Institution :
Dept. of Mech. & Aerosp. Eng., New Mexico State Univ., Las Cruces, NM
fDate :
4/1/2009 12:00:00 AM
Abstract :
This paper describes a dynamics modeling and control strategy of a chemo-electro-mechanical process for electroporation-mediated gene delivery. By extending the results in the open literature, a control-enabled dynamics model of the gene-delivery process is proposed. Based on the dynamics model, a model-based state feedback control strategy is proposed. Simulation results are provided to demonstrate the benefits and limitations of the proposed method.
Keywords :
biocontrol; bioelectric phenomena; biomembrane transport; cellular biophysics; electromechanical effects; genetics; nonlinear dynamical systems; chemo-electro-mechanical process; dynamics modeling; electroporation-mediated gene delivery contrrol; model-based state feedback control; Control; drug delivery; dynamics; electroporation; gene delivery; modeling; simulation;
Journal_Title :
Automation Science and Engineering, IEEE Transactions on
DOI :
10.1109/TASE.2008.917138
