DocumentCode
1105496
Title
Dynamics Modeling and Control of Electroporation-Mediated Gene Delivery
Author
Ma, Ou ; Zhang, Mingjun
Author_Institution
Dept. of Mech. & Aerosp. Eng., New Mexico State Univ., Las Cruces, NM
Volume
6
Issue
2
fYear
2009
fDate
4/1/2009 12:00:00 AM
Firstpage
228
Lastpage
238
Abstract
This paper describes a dynamics modeling and control strategy of a chemo-electro-mechanical process for electroporation-mediated gene delivery. By extending the results in the open literature, a control-enabled dynamics model of the gene-delivery process is proposed. Based on the dynamics model, a model-based state feedback control strategy is proposed. Simulation results are provided to demonstrate the benefits and limitations of the proposed method.
Keywords
biocontrol; bioelectric phenomena; biomembrane transport; cellular biophysics; electromechanical effects; genetics; nonlinear dynamical systems; chemo-electro-mechanical process; dynamics modeling; electroporation-mediated gene delivery contrrol; model-based state feedback control; Control; drug delivery; dynamics; electroporation; gene delivery; modeling; simulation;
fLanguage
English
Journal_Title
Automation Science and Engineering, IEEE Transactions on
Publisher
ieee
ISSN
1545-5955
Type
jour
DOI
10.1109/TASE.2008.917138
Filename
4473033
Link To Document