DocumentCode
1112090
Title
Detection and Visualization of Surface-Pockets to Enable Phenotyping Studies
Author
Mosaliganti, Kishore ; Janoos, Firdaus ; Sharp, Richard ; Ridgway, Randall ; Machiraju, Raghu ; Huang, Kun ; Wenzel, Pamela ; DeBruin, Alain ; Leone, Gustavo ; Saltz, Joel
Author_Institution
Ohio State Univ., Columbus
Volume
26
Issue
9
fYear
2007
Firstpage
1283
Lastpage
1290
Abstract
In this paper, we propose a technique for detecting pockets on a surface-of-interest. A sequence of propagating fronts converging to the target surface is used as the basis for inspection. We compute a correspondence function between the initial and the target surface. This leads to a natural definition of the local feature size measured as the evolution distance between mapped points. Surface pockets are then extracted as salient clusters embedded in the feature space. The level-set initialization also determines the scale-space of the extracted pockets. Results are presented on a case-study in which the focus is to chronicle the phenotyping differences in genetically modified mouse placenta. Our results are validated based on manually verified ground-truth.
Keywords
medical image processing; converging propagating front sequence; correspondence function; genetically modified mouse placenta; ground truth; local feature size definition; phenotyping studies; surface pocket detection; surface pocket visualization; Biomedical engineering; Biomedical imaging; Computer science; Drugs; Mice; Proteins; Surface fitting; Surface morphology; Surface reconstruction; Visualization; Computational phenotyping; level-sets; surface-pockets; Algorithms; Animals; Artificial Intelligence; Female; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Mice; Pattern Recognition, Automated; Phenotype; Placenta; Placenta Diseases; Pregnancy; Pregnancy, Animal; Reproducibility of Results; Retinoblastoma Protein; Sensitivity and Specificity; Surface Properties; User-Computer Interface;
fLanguage
English
Journal_Title
Medical Imaging, IEEE Transactions on
Publisher
ieee
ISSN
0278-0062
Type
jour
DOI
10.1109/TMI.2007.903570
Filename
4298154
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