• DocumentCode
    1112090
  • Title

    Detection and Visualization of Surface-Pockets to Enable Phenotyping Studies

  • Author

    Mosaliganti, Kishore ; Janoos, Firdaus ; Sharp, Richard ; Ridgway, Randall ; Machiraju, Raghu ; Huang, Kun ; Wenzel, Pamela ; DeBruin, Alain ; Leone, Gustavo ; Saltz, Joel

  • Author_Institution
    Ohio State Univ., Columbus
  • Volume
    26
  • Issue
    9
  • fYear
    2007
  • Firstpage
    1283
  • Lastpage
    1290
  • Abstract
    In this paper, we propose a technique for detecting pockets on a surface-of-interest. A sequence of propagating fronts converging to the target surface is used as the basis for inspection. We compute a correspondence function between the initial and the target surface. This leads to a natural definition of the local feature size measured as the evolution distance between mapped points. Surface pockets are then extracted as salient clusters embedded in the feature space. The level-set initialization also determines the scale-space of the extracted pockets. Results are presented on a case-study in which the focus is to chronicle the phenotyping differences in genetically modified mouse placenta. Our results are validated based on manually verified ground-truth.
  • Keywords
    medical image processing; converging propagating front sequence; correspondence function; genetically modified mouse placenta; ground truth; local feature size definition; phenotyping studies; surface pocket detection; surface pocket visualization; Biomedical engineering; Biomedical imaging; Computer science; Drugs; Mice; Proteins; Surface fitting; Surface morphology; Surface reconstruction; Visualization; Computational phenotyping; level-sets; surface-pockets; Algorithms; Animals; Artificial Intelligence; Female; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Mice; Pattern Recognition, Automated; Phenotype; Placenta; Placenta Diseases; Pregnancy; Pregnancy, Animal; Reproducibility of Results; Retinoblastoma Protein; Sensitivity and Specificity; Surface Properties; User-Computer Interface;
  • fLanguage
    English
  • Journal_Title
    Medical Imaging, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0278-0062
  • Type

    jour

  • DOI
    10.1109/TMI.2007.903570
  • Filename
    4298154