• DocumentCode
    1120358
  • Title

    Engineering in genomics

  • Author

    Brett, David ; Droege, Marcus ; Weber-Lehmann, Jacqueline

  • Volume
    23
  • Issue
    4
  • fYear
    2004
  • Firstpage
    74
  • Lastpage
    76
  • Abstract
    As bacterial genomic data accumulates in the public domain and the price of genomic sequencing falls, comparative-sequencing projects between multiple strains become an affordable option for both medical microbiologists and commercial firms interested in large-scale fermentation. To meet this need, biotech firms like MWG must first build up experience in bacterial whole genome sequencing and detailed gene annotation. There is also a need to combine this experience with bioinformatics and know how to be able to carry out useful comparative strain analysis. Finally, flexibility with bioinformatics and software offering to "customerize" the project to meet individual needs are necessary. It is believed that the approach outlined is an ideal and affordable way to tackle the issue of comparative sequence analysis.
  • Keywords
    biological techniques; biology computing; biotechnology; genetic engineering; genetics; microorganisms; MWG; bacterial genomic data; bioinformatics; biotech firms; commercial firms; comparative-sequencing projects; detailed gene annotation; genetic engineering; genomic sequencing; large-scale fermentation; medical microbiologists; multiple strains; Bioinformatics; Capacitive sensors; Cloning; DNA; Genetic mutations; Genomics; Libraries; Microorganisms; Production; Sequences; Algorithms; Computational Biology; DNA Mutational Analysis; DNA, Bacterial; DNA, Fungal; Gene Expression Profiling; Genetic Engineering; Genomics; Industrial Microbiology; Sequence Alignment; Sequence Analysis, DNA; Software; User-Computer Interface;
  • fLanguage
    English
  • Journal_Title
    Engineering in Medicine and Biology Magazine, IEEE
  • Publisher
    ieee
  • ISSN
    0739-5175
  • Type

    jour

  • DOI
    10.1109/MEMB.2004.1337953
  • Filename
    1337953