Title :
Gaussian Process Robust Regression for Noisy Heart Rate Data
Author :
Stegle, Oliver ; Fallert, Sebastian V. ; MacKay, David J C ; Brage, Søren
Author_Institution :
Dept. of Phys., Cambridge Univ., Cambridge
Abstract :
Heart rate data collected during nonlaboratory conditions present several data-modeling challenges. First, the noise in such data is often poorly described by a simple Gaussian; it has outliers and errors come in bursts. Second, in large-scale studies the ECG waveform is usually not recorded in full, so one has to deal with missing information. In this paper, we propose a robust postprocessing model for such applications. Our model to infer the latent heart rate time series consists of two main components: unsupervised clustering followed by Bayesian regression. The clustering component uses auxiliary data to learn the structure of outliers and noise bursts. The subsequent Gaussian process regression model uses the cluster assignments as prior information and incorporates expert knowledge about the physiology of the heart. We apply the method to a wide range of heart rate data and obtain convincing predictions along with uncertainty estimates. In a quantitative comparison with existing postprocessing methodology, our model achieves a significant increase in performance.
Keywords :
Bayes methods; Gaussian noise; electrocardiography; medical signal processing; pattern clustering; regression analysis; signal denoising; time series; Bayesian regression; ECG waveform; Gaussian process; clustering component; latent heart rate time series; noisy heart rate data; physiology; robust postprocessing model; uncertainty estimation; unsupervised clustering; Bayesian methods; Biological system modeling; Electrocardiography; Gaussian noise; Gaussian processes; Heart rate; Laboratories; Large-scale systems; Noise robustness; Physics; Physiology; Uncertainty; Gaussian Process; Gaussian process (GP); Heart rate; heart rate; noise; robust regression; Arrhythmias, Cardiac; Artifacts; Data Interpretation, Statistical; Electrocardiography; Heart Rate; Humans; Normal Distribution; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2008.923118