Micro-Organism-on-Chip: Emerging Direct-Write CMOS-Based Platform for Biological Applications

We describe the emerging applications of direct-write CMOS-based lab-on-chip which consists of capacitive sensors integrated with microfluidic structures. The microfluidic components are implemented through direct-write microfabrication process (DWFP) on a variety of substrates including integrated circuits. We put forward the recent advances of DWFP for different applications while our focus is placed on biological testing through a novel on-chip capacitive measurement method. We thereafter reveal the viability of this approach for biosensing purposes by demonstrating and discussing the experimental results on micro-organisms. These results are in full agreement with the bio-interface model and other features presented throughout the paper.