Title :
Charged Magnetic Nanoparticles for Enhancing Gene Transfection
Author :
Wang, Xiaoliang ; Zhou, Linzhu ; Ma, Yongjie ; Gu, Hongchen
Author_Institution :
Med-X Inst., Shanghai Jiao Tong Univ., Shanghai
fDate :
3/1/2009 12:00:00 AM
Abstract :
Magnetite nanoparticles were surface modified with five kinds of agents and used to enhance gene transfection. Standard polyethyleneimine (PEI) transfections were found to be enhanced only for the magnetic nanoparticles with strong surface potentials, since these can form complexes with PEI or genes via electrostatic interactions. Thus, it is not necessary to prepare gene-vector-coated magnetic nanoparticles for magnetofection.
Keywords :
biochemistry; bioelectric potentials; biomagnetism; cellular biophysics; gene therapy; magnetic particles; molecular biophysics; nanoparticles; nanotechnology; polymers; proteins; surface potential; PEI; charged magnetite nanoparticles; electrostatic interaction; gene transfection enhancement; magnetofection; polyethyleneimine transfection; surface potential; Magnetic nanoparticles; magnetofection; polyethyleneimine (PEI);
Journal_Title :
Nanotechnology, IEEE Transactions on
DOI :
10.1109/TNANO.2009.2013946
