Paper-based Raman spectroscopy for on-site therapeutic drug monitoring

This study proposes Raman spectroscopy of tear fluid with paper substrates for on-site therapeutic drug monitoring(TDM). In this method, the paper substrates are used for tear sample collection and measurement. The use of paper offers a minimally-invasive, simple, and inexpensive method for therapeutic drug monitoring. To demonstrate the usability of the paper substrates for this purpose, we measured Raman spectra of samples containing therapeutic drug and glucose with a filter paper. Experimental results show the ability to detect Raman signals from the samples absorbed on the paper substrate.