Title :
Variable-length haplotype construction for geneߝgene interaction studies
Author :
Assawamakin, Anunchai ; Chaiyaratana, Nachol ; Limwongse, Chanin ; Sinsomros, Saravudh ; Yenchitsomanus, Pa-thai ; Youngkong, Prakarnkiat
Abstract :
Genetic epidemiology is a research field that aims to identify genetic polymorphisms that are involved in disease susceptibility. In this article, a variable-length haplotype construction for gene-gene interaction (VarHAP) technique is proposed. The technique will involve nonparametric classification where haplotypes inferred from multiple single nucleotide polymorphism (SNP) data are the classifier inputs.
Keywords :
classification; diseases; genetics; medical computing; molecular biophysics; polymorphism; disease susceptibility; gene-gene interaction; genetic epidemiology; nonparametric classification approach; single nucleotide polymorphism; variable-length haplotype construction; Availability; Bioinformatics; Costs; Diseases; Genetics; Logistics; Neural networks; Organisms; Protocols; Testing; Algorithms; Databases, Genetic; Epistasis, Genetic; Haplotypes; Linkage Disequilibrium; Models, Genetic; Pattern Recognition, Automated; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Statistics, Nonparametric;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2009.932902
