• DocumentCode
    1144897
  • Title

    Pharmocokinetics of dicarboxylic acids in man

  • Author

    Bertuzzi, A. ; Gandolfi, A. ; Salinari, S. ; Mingrone, G. ; Greco, A.V.

  • Author_Institution
    Istituto di Analisi dei Sistemi ed Inf., CNR, Rome, Italy
  • Volume
    13
  • Issue
    4
  • fYear
    1994
  • Firstpage
    472
  • Lastpage
    478
  • Abstract
    In order to study the feasibility of using dicarboxylic acids for parenteral nutrition, the authors studied the pharmacokinetics in man of azelaic acid and sebacic acid. The pharmacokinetic analysis presented here shows that there are different modalities in the urinary excretion of the dicarboxylic acids with 9 or 10 carbon atoms. While azelaic acid seems to be actively secreted, sebacic acid is actively reabsorbed.<>
  • Keywords
    kidney; organic compounds; physiology; active reabsorption; active secretion; azelaic acid; dicarboxylic acids; parenteral nutrition; pharmacokinetic analysis; sebacic acid; urinary excretion modalities; Biochemistry; Biomedical engineering; Blood; Diabetes; Intrusion detection; Organisms; Oxidation; Plasmas; Production; Sugar;
  • fLanguage
    English
  • Journal_Title
    Engineering in Medicine and Biology Magazine, IEEE
  • Publisher
    ieee
  • ISSN
    0739-5175
  • Type

    jour

  • DOI
    10.1109/51.310987
  • Filename
    310987
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1144897