Title :
Pharmocokinetics of dicarboxylic acids in man
Author :
Bertuzzi, A. ; Gandolfi, A. ; Salinari, S. ; Mingrone, G. ; Greco, A.V.
Author_Institution :
Istituto di Analisi dei Sistemi ed Inf., CNR, Rome, Italy
Abstract :
In order to study the feasibility of using dicarboxylic acids for parenteral nutrition, the authors studied the pharmacokinetics in man of azelaic acid and sebacic acid. The pharmacokinetic analysis presented here shows that there are different modalities in the urinary excretion of the dicarboxylic acids with 9 or 10 carbon atoms. While azelaic acid seems to be actively secreted, sebacic acid is actively reabsorbed.<>
Keywords :
kidney; organic compounds; physiology; active reabsorption; active secretion; azelaic acid; dicarboxylic acids; parenteral nutrition; pharmacokinetic analysis; sebacic acid; urinary excretion modalities; Biochemistry; Biomedical engineering; Blood; Diabetes; Intrusion detection; Organisms; Oxidation; Plasmas; Production; Sugar;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
