Title :
Finite element modeling of dielectrophoretic microelectrodes based on a array and ratchet type
Author :
Buyong, Muhamad Ramdzan ; Abd Aziz, Norazreen ; Hamzah, Azrul Azlan ; Mohd Razip Wee, M.F. ; Majlis, Burhanuddin Yeop
Author_Institution :
Inst. of Microeng. & Nanoelectronic (IMEN), Univ. Kebangsaan Malaysia (UKM), Bangi, Malaysia
Abstract :
This research describes an investigation of nonuniform electric field for dielectrophoretic forces (FDEP) application in particles and cells manipulation. In an electro kinetics occurrence, a miniaturized array and ratchet type microelectrodes has been simulated. The study of optimal FDEP behavior on the electric field distribution for both type microelectrodes was characterized and optimized by finite element method, (FEM). A set of array and ratchet type microelectrode are biased to generate asymmetric electric field distribution. Normalization of microelectrode simulation result shows that array and ratchet type produced a comparable electric field strength and direction. Deployment of additional dimension for array type electrode, three poles produced the highest of electric field strength of 7.513 e7 V/m and displacement field direction of 2.758 e-3 C/m2. Simulation results are used to design a higher sensitive and selective of a dielectrophoretic (DEP) microelectrode for selection, collection and processing of particle and cell using optimal FDEP that determination advancement in the development of dielectrophoretic a lab-on-a-chip. Ultimately, the findings of this work is possible to contribute in medical sciences research for the enrichment of stem cell from bone narrow and peripheral blood form via integration DEP into a lab on a chip, (DLOC) concept application.
Keywords :
bioelectric potentials; biomedical electrodes; blood; bone; cellular biophysics; electrophoresis; finite element analysis; lab-on-a-chip; microelectrodes; FEM; asymmetric electric field distribution; bone narrow; cell manipulation; dielectrophoretic force application; dielectrophoretic microelectrodes; displacement field direction; electric field direction; electric field distribution; electric field strength; electrokinetic occurrence; finite element modeling; lab-on-a-chip; medical sciences research; microelectrode simulation; miniaturized array; nonuniform electric field; normalization; particle manipulation; peripheral blood; ratchet-type microelectrodes; stem cell enrichment; Arrays; Dielectrophoresis; Finite element analysis; Microelectrodes; Nonuniform electric fields; Microelectrode; dielectrophoretic; lab-on-a-chip;
Conference_Titel :
Semiconductor Electronics (ICSE), 2014 IEEE International Conference on
Conference_Location :
Kuala Lumpur
DOI :
10.1109/SMELEC.2014.6920840