Title :
Modelling essential interactions between synthetic genes and their chassis cell
Author :
Algar, R.J.R. ; Ellis, T. ; Stan, G.-B.
Author_Institution :
Dept. of Bioeng., Imperial Coll. London, London, UK
Abstract :
In this paper we develop a model of gene expression for the purpose of studying the resource use of synthetic gene circuits when expressed in chassis cells. This model focuses on the translational aspect of gene expression which accounts for the majority of resource usage. The model allows for simulations of circuit-chassis interactions that can be used to inform improved designs of synthetic gene circuits.
Keywords :
biology; cellular biophysics; genetics; chassis cell; circuit-chassis interaction simulation; essential interaction modeling; gene expression translational aspect; synthetic gene circuits; Biological system modeling; Equations; Erbium; Integrated circuit modeling; Mathematical model; Random variables; Synthetic biology; Circuit-Chassis Interactions; Ribosomal Availability; Synthetic Biology; Translational Model;
Conference_Titel :
Decision and Control (CDC), 2014 IEEE 53rd Annual Conference on
Conference_Location :
Los Angeles, CA
Print_ISBN :
978-1-4799-7746-8
DOI :
10.1109/CDC.2014.7040239
