DocumentCode :
1170133
Title :
Pulsed Doppler signal processing for use in mice: applications
Author :
Reddy, Anilkumar K. ; Taffet, George E. ; Li, Yi-Heng ; Lim, Sang-Wook ; Pham, Thuy T. ; Pocius, Jennifer S. ; Entman, Mark L. ; Michael, Lloyd H. ; Hartley, Craig J.
Author_Institution :
Baylor Coll. of Med., Houston, TX, USA
Volume :
52
Issue :
10
fYear :
2005
Firstpage :
1771
Lastpage :
1783
Abstract :
We have developed a high-frequency, high-resolution Doppler spectrum analyzer (DSPW) and compared its performance against an adapted clinical Medasonics spectrum analyzer (MSA) and a zero-crossing interval histogram (ZCIH) used previously by us to evaluate cardiovascular physiology in mice. The aortic velocity (means ± SE: 92.7 ± 2.5 versus 82.2 ± 1.8 cm/s) and aortic acceleration (8194 ± 319 versus 5178 ± 191 cm/s2) determined by the DSPW were significantly higher compared to those by the MSA. Aortic ejection time was shorter (48.3± 0.9 versus 64.6 ± 1.8 ms) and the isovolumic relaxation was longer (17.6 ± 0.6 versus 13.5 ±0.6 ms) when determined by the DSPW because it generates shorter temporal widths in the velocity spectra when compared to the MSA. These data indicate that the performance of the DSPW in evaluating cardiovascular physiology was better than that of the MSA. There were no significant differences between the aortic pulse wave velocity determined by using the ZCIH (391 ± 16 cm/s) and the DSPW (394 ± 20 cm/s). Besides monitoring cardiac function, we have used the DSPW for studying peripheral vascular physiology in normal, transgenic, and surgical models of mice. Several applications such as the detection of high stenotic jet velocities (>4 m/s), vortex shedding frequencies (250 Hz), and subtle changes in wave shapes in peripheral vessels which could not obtained with clinical Doppler systems are now made possible with the DSPW.
Keywords :
Doppler measurement; cardiovascular system; haemodynamics; medical signal processing; patient monitoring; spectral analysers; 250 Hz; 47.4 to 59.2 ms; 62.8 to 66.4 ms; Medasonics spectrum analyzer; aortic acceleration; aortic ejection; aortic velocity; cardiac function monitoring; cardiovascular physiology; high-frequency high-resolution Doppler spectrum analyzer; isovolumic relaxation; mice; peripheral vessels; pulsed Doppler signal processing; stenotic jet velocities; zero-crossing interval histogram; Acceleration; Cardiology; Frequency; Histograms; Mice; Monitoring; Physiology; Signal processing; Spectral analysis; Surgery; High-frequency pulsed Doppler ultrasound; mouse cardiac function; mouse cardiovascular physiology; pulse-wave velocity; stenotic jet velocities; vortex shedding frequencies; Algorithms; Animals; Aortic Valve Stenosis; Artificial Intelligence; Blood Flow Velocity; Echocardiography, Doppler, Pulsed; Equipment Design; Equipment Failure Analysis; Hemorheology; Image Interpretation, Computer-Assisted; Mice; Signal Processing, Computer-Assisted;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2005.855709
Filename :
1510861
Link To Document :
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