Title :
The DNA SET: a novel device for single-molecule DNA sequencing
Author :
Mali, P. ; Lal, R.K.
Author_Institution :
Dept. of Electr. Eng., Indian Inst. of Technol. Mumbai, India
Abstract :
We present the principle of the dnaSET, a novel device for single-molecule sequence analysis of DNA strands. The central idea is to measure the variations in current through a single electron transistor (SET) as a target DNA molecule slithers through a nanoeye integrated between the SET´s floating island and gate. We present a basic but illustrative simulation of the operation, and the results therefrom lead us to conclude that the DNA SET has a single-nucleotide resolution that enables it to read off the individual bases in a DNA strand. The versatility of this idea makes it suitable for incorporation in other bio-assay tools, and thus the DNA/protein SET promises to be a powerful direct sensing device for a wide range of applications.
Keywords :
DNA; biosensors; single electron transistors; DNA SET; DNA chip; DNA sensors; DNA strands; affinity sensors; bio-assay tools; deoxyribonucleic acid; powerful direct sensing device; sequence analysis; single electron transistor; single-molecule DNA sequencing; single-molecule sensing; single-stranded DNA; Biomedical transducers; DNA; Affinity sensors; DNA chip/sensors; deoxyribonucleic acid (DNA); dnaSET; nanoeye; sequence analysis; single electron transistor (SET); single-molecule sensing; single-stranded DNA (ssDNA);
Journal_Title :
Electron Devices, IEEE Transactions on
DOI :
10.1109/TED.2004.839740